Using read-across approach to assess the hazardous properties of
「Using read-across approach to assess the hazardous properties of」於資料集「EPQSummary_ChemicalSubstanceManagement」由單位「行政院環境保護署」的陳先生所提供，聯繫電話是02-2311-7722#2386，最近更新時間為：2023-07-30 01:01:48。 欄位Project Title的內容是Using read-across approach to assess the hazardous properties of UVCBs: A preliminary project ， 欄位Project Subject的內容是In recent years, our government has facilitated the local version of “Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)” to achieve the source control of chemicals in Taiwan. Our government amended the administrative law, “Regulations of New and Existing Chemical Substances Registration,” on March 11th, 2019, to regulate the chemical registration for new and existing chemical substances, including the new chemicals’ small quantity registration, simplified registration, and standard registration. The registration and management of unknown or variable composition, complex reaction products or biological materials (UVCBs) is a critical challenge for regulatory agencies because UVCBs usually have unknown components, complex and variable composition, and batch-to-batch variability. Substance characterization and hazard identification of UVCBs becomes a critical issue to resolve by the registrants and regulatory agencies. Read-across is a practical approach to filling toxicity gaps of UVCBs. However, we are still at the initial stage of applying read-across in chemical management and assessment. This project aims to establish the assessment and regulatory framework of UVCBs in Taiwan. We investigated the current regulatory frameworks for UVCB registration in the European Union and the United States. We reviewed the latest development of UVCB assessment and management (e.g., chemical-biological read-across, CBRA). We designed a UVCB case study in Taiwan to demonstrate how to facilitate the read-across of UVCBs using experimental approaches such as high-content imaging and untargeted chemical analyses. Herein, we evaluated the feasibility of establishing the similarity of UVCBs using chemical and biological data, which would facilitate the chemical registration of UVCBs. Results from this project show that using boiling point data and bioactivity data with nonparametric clustering methods provides the best grouping results of the lubricant UVCBs. ， 欄位Project Year的內容是2021 ， 欄位Organizer的內容是Toxic and Chemical Substances Bureau ， 欄位Executive Unit的內容是國立臺灣大學 ， 欄位Reporting download URL的內容是https://epq.epa.gov.tw/ProjectDoc/FileDownload?fid=292451&proj_id=1100739119&doc_kind=1 ， 欄位Publish Date的內容是20230111 。
Project Title
Using read-across approach to assess the hazardous properties of UVCBs: A preliminary project
Project Subject
In recent years, our government has facilitated the local version of “Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)” to achieve the source control of chemicals in Taiwan. Our government amended the administrative law, “Regulations of New and Existing Chemical Substances Registration,” on March 11th, 2019, to regulate the chemical registration for new and existing chemical substances, including the new chemicals’ small quantity registration, simplified registration, and standard registration. The registration and management of unknown or variable composition, complex reaction products or biological materials (UVCBs) is a critical challenge for regulatory agencies because UVCBs usually have unknown components, complex and variable composition, and batch-to-batch variability. Substance characterization and hazard identification of UVCBs becomes a critical issue to resolve by the registrants and regulatory agencies. Read-across is a practical approach to filling toxicity gaps of UVCBs. However, we are still at the initial stage of applying read-across in chemical management and assessment. This project aims to establish the assessment and regulatory framework of UVCBs in Taiwan. We investigated the current regulatory frameworks for UVCB registration in the European Union and the United States. We reviewed the latest development of UVCB assessment and management (e.g., chemical-biological read-across, CBRA). We designed a UVCB case study in Taiwan to demonstrate how to facilitate the read-across of UVCBs using experimental approaches such as high-content imaging and untargeted chemical analyses. Herein, we evaluated the feasibility of establishing the similarity of UVCBs using chemical and biological data, which would facilitate the chemical registration of UVCBs. Results from this project show that using boiling point data and bioactivity data with nonparametric clustering methods provides the best grouping results of the lubricant UVCBs.
Project Year
2021
Organizer
Toxic and Chemical Substances Bureau
Executive Unit
國立臺灣大學
Reporting download URL
https://epq.epa.gov.tw/ProjectDoc/FileDownload?fid=292451&proj_id=1100739119&doc_kind=1
Publish Date
20230111
「Using read-across approach to assess the hazardous properties of」所屬的資料集：「EPQSummary_ChemicalSubstanceManagement」的其他資料
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